Bullock said she had an "incredible ride" and praised her fellow nominees: Meryl Streep, Gabourey Sidibe, Helen Mirren and Carey Mulligan.
"The Blind Side," was also nominated for best picture.
Sandra Bullock not only took home an Oscar for best actress but also was the evening's best dressed, according to a TVGuide.com poll and E! Television.
Bingham and Burnett's "The Weary Kind" is the theme song of the movie "Crazy Heart."
Best Picture: The Hurt Locker
Lead Actor: Jeff Bridges (Crazy Heart)
Lead Actress: Sandra Bullock (Blind Side)
Supporting Actor: Christoph Waltz (Inglorious Basterds)
Supporting Actress: Mo'Nique (Precious)
Director: Kathryn Bigelow (The Hurt Locker)
Original Screenplay: The Hurt Locker
Best Animated Film: Up